Clinical Trials

Current Trials

Wet Age-Related Macular Degeneration

  • Allergan 150998-005 – A Safety and Efficacy Study of Abicipar Pegol in Patients With Neovascular Age-related Macular Degeneration (Now Enrolling)
  • OHR-1601 – A Phase III Study of the Efficacy and Safety of Squalamine Lactate Ophthalmic Solution, 0.2% Twice Daily in Subjects with Neovascular Age-Related Macular Degeneration (Now Enrolling)
  • Iconic hI-con1 – A Phase 2 Randomized, Double-masked, Multicenter, Active-controlled Study Evaluating Administration of Repeated Intravitreal Doses of hI-con1™ in Patients with Choroidal Neovascularization Secondary to Age-related Macular Degeneration (Enrollment Closed)
  • Alcon RTH258 – A Two-Year, Randomized, Double-Masked, Multicenter, Three-Arm Study Comparing the Efficacy and Safety of RTH258 versus Aflibercept in Subjects with Neovascular Age-Related Macular Degeneration (Enrollment Closed)

Dry Age-Related Macular Degeneration with Geographic Atrophy

  • Alcon CLG561 – A randomized, multi-center, single masked, sham controlled, proof-of –concept study of intravitreal CLG561 as a monotherapy or in combination with LFG316 in patients with geographic atrophy (Now Enrolling)

Diabetic Retinopathy Clinical Research Network DRCR (Now Enrolling)

  • Protocol U – Short-term Evaluation of Combination Corticosteroid + Anti-VEGF Treatment for Persistent Central-Involved Diabetic Macular Edema Following Anti-VEGF Therapy
  • Protocol V – Treatment for Central-Involved Diabetic Macular Edema in Eyes with Very Good Visual Acuity
  • Protocol W – Intravitreous Anti-VEGF Treatment for Prevention of Vision Threatening Diabetic Retinopathy in Eyes at High Risk
  • Protocol AA — Peripheral Diabetic Retinopathy (DR) Lesions on Ultrawide-field Fundus Images and Risk of DR Worsening Over Time
  • Genes in Diabetic Retinopathy Project

Diabetic Retinopathy Clinical Research Network DRCR (Enrollment Closed)

  • Protocol S : Prompt Panretinal Photocoagulation Versus Intravitreal Ranibizumab with Deferred Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
  • Protocol T : Intravitreal Bevacizumab Compared with Intravitreal Ranibizumab for Diabetic Macular Edema

Retinal Vein Occlusion

  • SCORE2 – A Multicenter, Prospective, Randomized, Phase III, Non-Inferiority Trial of Eyes with Macular Edema Secondary to Central Retinal Vein Occlusion, Comparing Intravitreal Bevacizumab Versus Intravitreal Aflibercept (Enrollment Closed)

Past Trials


  • “Seattle” Safety and Efficacy Assessment Treatment Trials of Emixustat Hydrochloride

Diabetic Retinopathy Clinical Research Network DRCR Studies

  • Protocol “L”: Evaluation of Visual Acuity Measurements in Eyes with Diabetic Macular Edema
  • Protocol “N”: An Evaluation of Intravitreal Ranibizumab for Vitreous Hemorrhage due to Proliferative Diabetic Retinopathy
  • Protocol “P”: A pilot Study in Individuals with Center-Involved Diabetic Macular Edema Undergoing Cataract Surgery
  • Protocol “Q”: An Observational Study in Individuals with Diabetic Retinopathy Without Center-Involved DME Undergoing Cataract Surgery.


  • “MATISSE Study” PF-04523655 Dose Escalation Study, and Evaluation of PF-04523655 With/Without Ranibizumab in Diabetic Macular Edema (DME)


  • A 16 Week Evaluation of the Novartis Health Management Tool in Assessing Self-Test Visual Function in Patients with AMD treated with Lucentis


  • “TG-MV-006” A Randomized, Placebo Controlled, Double-Masked, Multicenter Trial of Micropalsmin Intravitreal Injection for Non-Surgical Treatment of Focal Vitreomacular Adhesion
  • “Oasis” A Randomized, Sham-Controlled, Double-Masked, Multicenter Study Evaluating Ocriplasmin Treatment for Symptomatic Vitreomacular Adhesion (VMT) Including Macular Hole.


  • “DIAMOND Study” DR-002. A Phase 2, Double-Masked, Placebo-Controlled, Dose-Ranging Clinical Study to Assess the Safety and Efficacy of Subconjunctival Injections of Sirolimus in Patients with Diabetic Macular Edema Secondary to Diabetic Retinopathy”
  • “Emerald Study” AMD-003. A Phase 2, Randomized, Masked, Controlled Clinical Study to Assess the Safety and Efficacy of Lucentis plus Sirolimus versus Lucentis Plus Placebo in Patients with Sub-Foveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration.

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